Skeletal muscle mitochondrial DNA content in exercising humans
نویسندگان
چکیده
منابع مشابه
Skeletal muscle mitochondrial DNA content in exercising humans.
Several weeks of intense endurance training enhances mitochondrial biogenesis in humans. Whether a single bout of exercise alters skeletal muscle mitochondrial DNA (mtDNA) content remains unexplored. Double-stranded mtDNA, estimated by slot-blot hybridization and real time PCR and expressed as mtDNA-to-nuclear DNA ratio (mtDNA/nDNA) was obtained from the vastus lateralis muscle of healthy human...
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Cumulative mtDNA damage occurs in aging animals, and mtDNA mutations are reported to accelerate aging in mice. We determined whether aging results in increased DNA oxidative damage and reduced mtDNA abundance and mitochondrial function in skeletal muscle of human subjects. Studies performed in 146 healthy men and women aged 18-89 yr demonstrated that mtDNA and mRNA abundance and mitochondrial A...
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BACKGROUND Exhausting exercise reduces the mitochondrial DNA (mtDNA) content in the skeletal muscle of healthy subjects due to oxidative damage. Since patients with chronic obstructive pulmonary disease (COPD) suffer enhanced oxidative stress during exercise, it was hypothesised that the mtDNA content will be further reduced. OBJECTIVE To investigate the effects of exercise above and below th...
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BACKGROUND The decline in muscle mass (sarcopenia) with aging may be related to a decline in mitochondrial function. However, investigators have yet to reach a consensus as to whether a decline in mitochondrial function can be attenuated by physical activity has yet to reach a consensus. METHODS Using dynamic 31PMRS to measure mitochondrial function, we measured baseline Phosphocreatine (PCr)...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2005
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00289.2005